Wojciech Perdzyński, Would you think this could have an effect, when used during regular dilatations a patient undergoes before urethroplasty. In our research group we were thinking along those lines.

As a rule we are against urethral dilatations, which may produce some injury into urethra, especially that with hard, non-expandable scars. We use only calibrations, that means we introduce dilator which is the same size as actual internal size of urethra. That exclude possibility of urethral injury, which may be the case during dilatations. All patients we described in our paper had had many urethral operations including reoperations for urethral stricture, dilatations as well as endoscopic incisions. In most of them I felt - by palpation - hard scars along penile urethra. That`s why we decided to perform BMGU and after 5 weeks, after measuring internal urethral caliber we started calibrations with anti-scar gel which were followed by patients under our supervision from time to time. We are convinced that best results of that treatment can be obtained during early remodelling phase of postoperative wound healing (it may lasts usually for one year, but some scientists consider that may lasts even for several years) in which anti-scar gel can prevent fibrosis as well as scar contracture, main cause of urethral stricture recurrency as I understand that process. In section Discussion of my paper process of wound healing is described as well as action of ant-iscar gel which may help to understand our attitude during that promising method of treatment.

Patients are very motivated to continue self-calibration with anti-scar gel because they suffereda lot for a long period of time due to serious problems with voiding as well as due to the painful memory of many operations followed by recurrence od urethral stricture.