Rotenone is indeed poorly water-soluble and will precipitate if dissolved directly in water.

For cell-based experiments, we recommend referring to our instructions. For animal experiments, we recommend using DMSO to prepare a stock solution. For animal experiments, we recommend calculating the dosage to ensure it meets experimental requirements.

If the DMSO solution is insufficient, we recommend using the 0.5% CMC-Na/saline water solution available on our official website. Prepare the solution fresh and use immediately.

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No, rotenone is poorly soluble in water; it is typically dissolved in organic solvents like ethanol, acetone, or DMSO for use.

Best,

Davide

Hello,

Rotenone is an odorless, colorless, crystalline isoflavone. It occurs naturally in the seeds and stems of several plants, such as the jicama vine, and in the roots of several other members of the Fabaceae. It was the first-described member of the family of chemical compounds known as rotenoids. Rotenone is approved for use as a piscicide to remove alien fish species,[3] see Uses. It has also been used as a broad-spectrum insecticide, but its use as an insecticide has been banned in many countries.

Solubility: Soluble in ether and acetone, slightly soluble in ethanol

https://en.wikipedia.org/wiki/Rotenone

Readily soluble in acetone, carbon disulfide, ethyl acetate and chloroform. Less readily soluble in diethyl ether, alcohols, petroleum ether and carbon tetrachloride.

MacBean C, ed; e-Pesticide Manual. 15th ed., ver. 5.1, Alton, UK; British Crop Protection Council. Rotenone(CAS 83-79-4) (2008-2010)

https://pubchem.ncbi.nlm.nih.gov/compound/Rotenone#section=Solubility

https://www.sciencedirect.com/topics/medicine-and-dentistry/rotenone