Yes, it is possible to assess Per- and Polyfluoroalkyl Substances (PFAS) using an Agilent 6420 LC/MS/MS system without the Jet Stream (AJS) ion source. The Agilent 6420 LC/MS/MS system is equipped with an Electrospray Ionization (ESI) source, which is commonly used for analyzing a wide range of compounds, including PFAS.

While the Jet Stream (AJS) technology can enhance sensitivity and performance, it is not strictly required for PFAS analysis. ESI is a widely used ionization technique that generates ions from a solution through the application of an electric field. It produces ions that are suitable for many compounds, including PFAS, without the need for Jet Stream technology.

Here are the steps to perform PFAS analysis on an Agilent 6420 LC/MS/MS system without the Jet Stream ion source:

While Jet Stream technology can enhance sensitivity, it's not mandatory for PFAS analysis on the Agilent 6420 LC/MS/MS system. With proper method development, sample preparation, and optimization of ESI parameters, you can successfully analyze PFAS using the standard ESI ion source available on the instrument. Anika Nawar

Sounds all correct to me. However, the real trouble with PFAS are the instrument blanks. So my eyes are actually more on the trapping column (between the pump and the autosampler) that will fetch out PFAS instrument blanks. - Good luck