Most studies on CAR-T cells use NSG mice (B/T cell deficient) based on the papers I found. Only a few use nude mice (T cell deficient, B cell present), which is what we are hoping to do. Does anyone have experience with using nude mice tumor model in CAR-T cell studies? What are the problems with using nude mice for CAR-T cell studies (since B cell is APC), and what are the potential solutions? Thanks a lot for any responses!  

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