It is hard to find data on anemia in pulmonary LCH. If the LCH is associated with bone marrow involvement (which is very rare with pulmonary LCH even in small children) then one would expect the anemia to be normocytic. If not then the association, if there is one, should be similar to that of anemia of chronic diasease. These can be microcytic. However, to me it seems more likely that the microcytic anemia is independent of the LCH eg due to iron deficiency.
It is hard to find data on anemia in pulmonary LCH. If the LCH is associated with bone marrow involvement (which is very rare with pulmonary LCH even in small children) then one would expect the anemia to be normocytic. If not then the association, if there is one, should be similar to that of anemia of chronic diasease. These can be microcytic. However, to me it seems more likely that the microcytic anemia is independent of the LCH eg due to iron deficiency.
Dear Fahim in two cases we published as LCH as Extra digestive H. pylori Skin manifestations (EdHpSm), anemia was associated as it is known that h. pylori affects Interinsic Factor (IF) which lead to aneamia as well its a known cause for cideroplastic too.
Bashir A. H. H.1,2*, Lamyaa A. M.2 and Al Hassan A. M.2. Langerhans cell histiocytosis (LCH) associated with Helicobacter pylori infection. Clinical Reviews and Opinions Vol. 3(4), pp. 45-50, June 2011
Available online http://www.academicjournals.org/cro
ISSN 2141-2553 ©20411 Academic Journals
1Adil HH Bashir and 2AM El Hassan. Adult Disseminated Cutaneous Langerhans
Cell Histocytosis with nail involvement in a Sudanese patient: a case report and review. Sudan J Dermatol 2009;Vol 7: 37 - 41.
Ahmed, I think, made her question because a patient with LCH had microcytic anemia. Theoretically we can have at least three hypotheses that may explain the microcytosis:
Thank you very much for the input. I think we need to presume that Anemia is unrelated to LCH until proven otherwise and I am investigating one patient with PLCH with GI investigations and update if somehow it links with LCH. Regards
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