Can anyone provide a research paper related to reversible encephalopathy caused by lithium in therapeutic range after a year of continuous therapy?
Do you saw these 2 recents publications ? and the last one on chronic intoxication in susceptible individuals ?
Article Lithium Toxicity at Therapeutic Blood Levels: A Case Report
Article Lithium Toxicity in an Elderly Women within Normal Therapeut...
Article Lithium Toxicity: An Iatrogenic Problem in Susceptible Individuals
Lithium has gained a lot of popularity for a while, specially in the era of dementia prevention. Lithium toxicity is relatively well understood. However, non-toxicity related possible side effects might include rebound progressive cognitive decline +/- brain atrophy as shown by this recent review.
http://www.ncbi.nlm.nih.gov/pubmed/25515130
Thanks Abdulhafeez Mohammad khair for your information but my query was related to lithium induced acute encephalopathy in therapeutic range.
Clinically, it clearly exists, as exemplified by the "Lithium tremor", which is phenomenologically indistinguishable from the irregular tremor encountered in mild metabolic encephalopathy. As Lithium acts partially in competition with Natrium, there may be some individuals genetically prone to this due to variations in the Na-canals. There have been attempts, already reaching back to the 90s, to work with lower therapeutic ranges (e.g. 0,6-0,8 instead of 0,8 to 1,2), which is certainly true for older patients. But definitive papers are very sparse, you may look for older ones on Li-induced-Parkinsons or Creutzfeldt-Jakob-likes of the 80ies and 90s. Unfortunately, I lost track of my own small collection, sorry.