Yes. There is experience of the efficacy of the pulse itraconazole (200 mg twice daily, 1 week on, 3 weeks off, for 12 weeks) vs. continuous terbinafine (250 mg once daily for 12 weeks) oral therapies in the treatment of dermatophyte toenail distal and lateral subungual onychomycosis (DLSO) in normal patients and in the diabetic population.
Dear Venkata, in case of onychomycosis, if toe nails also affected it is recommended to give Itraconazole pulse therapy twice a day in a dose of 200mg for 7 days then a lapse for 21 days and repeat for another 2 successive cycles i.e. 3 pulse doses 21 days in between.
single weekly dose of 400 mg itraconazole used instead of 200 mg twice day for seven days for tinea( pityriasis) versicolor. single dose appear to be better for improving compliance and decreased cost of treatment.. for further information please go through article..
Single dose (400 mg) versus 7 day (200 mg) daily dose itraconazole in the treatment of tinea versicolor: a randomized clinical trial.
Most data indicate the use of itraconazole twice a day in a dose of 200mg for 7 days then a lapse for 21 days and repeatition for another 2 successive cycles. However, the possibility of a weekly administration appears very promising especially to improve the compliance and reduce the costs. Probably, it is necessary to perform other randomized trials.
Duration of therapy: At least 3 weeks and for 2 weeks after symptoms resolve
Comments:
-Oral solution formulation
-Doses up to 200 mg/day may be used based on clinical judgment of patient response.
-The oral solution should be vigorously swished in the mouth (10 mL at a time) for several seconds and swallowed.
-Only the oral solution has demonstrated efficacy for oral and/or esophageal candidiasis.
IDSA Recommendations: 200 mg orally per day
Duration of therapy:2 to 3 weeks
Usual Pediatric Dose for Oral Thrush
IDSA Recommendations:
Oropharyngeal candidiasis in patients 5 years or older: 2.5 mg/kg orally twice a day
Comments:
-Oral solution formulation
CDC, NIH, IDSA, PIDS, and AAP Recommendations for HIV-exposed and HIV-infected Children:
Fluconazole-refractory oropharyngeal candidiasis: 2.5 mg/kg orally twice a day
Maximum dose: 400 mg/day
Duration of therapy: 1to 2 weeks
Secondary prophylaxis: 2.5 mg/kg orally twice a day
Usual Adult Dose for Onychomycosis - Fingernail
Treatment pulse: 200 mg orally twice a day for 1 week
Comments:
-Capsule formulation
-Fingernails only
-Diagnosis should be confirmed before starting therapy; appropriate nail specimens for laboratory testing (KOH preparation, fungal culture, nail biopsy) should be obtained.
-The recommended dosing regimen is 2 treatment pulses, which are separated by 3 weeks without treatment; the manufacturer product information should be consulted for further guidance.
Use: For the treatment of onychomycosis of the fingernail due to dermatophytes (tinea unguium) in non-immunocompromised patients.