Ischemia-reperfusion injury (IRI) is often associated with microvascular impairment, endothelial dysfunction and capillaries rarefaction.
This may affect proper RBC circulation within the microvasculature and can potentially exert mechanical stress on erythrocytes, eventually leading to their destruction.
>> Can IRI ultimately affect RBC count/hematocrit? Can this be a consequence of hemolysis due to mechanical stress on RBC?
Any reference about this topic is appreciated.
Thanks
Josselin Nespoux
Intravascular hemolysis can be triggered by two factors: an abnormal level of shear stress or increased mechanical fragility of red blood cells. I hope the following publications will be helpful.
Article Intravascular Hemolysis and Acute Renal Failure After Mitral...
Article Intravascular Hemolysis in Aluminum Phosphide Poisoning
Article Intravascular Hemolysis in Aortic Stenosis
Article Intravascular hemolysis and the pathophysiology of sickle cell disease
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