Chithan C Kandaswami
Azoxymethane is a suspected colon carcinogen in animals; it is a proximate metabolite of the procarcinogen, 1,2-dimethylhydrazine.
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Kosar Omidian
Thanks for your answer. Do u think it is practical to induce cancer in cell culture with azoxymethane?
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Chithan C Kandaswami
Kosar,
Carcinogen binding to DNA and other macromolecules can be studied using cultured cells, if they have the capacity to metabolize the carcinogen. Metabolism of carcinogens can also be studies with these cells. Cancer induction with a precarcinogen is done with experimental animals; cancer initiation needs an organ (liver, colon, etc.). There are certain protocols (exposure time, dose, etc.).
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