Can I replace the sodium ascorbate by L- proline in Click reactions and what reaction conditions?
The purpose of the ascorbic is to reduce Cu(II) to Cu(I) which is the catalytic active species. You can use proline if you want but you'd have to use a Cu(I) source such as CuI. There is an alternative, copper thiophene carboxylate (CuTC) is good to use in organic solvents and typically works really well. Typically we heat to 100 oC for about 30 mins to get a decent reaction using a 10 mol% catalyst loading.
The purpose of the ascorbic is to reduce Cu(II) to Cu(I) which is the catalytic active species. You can use proline if you want but you'd have to use a Cu(I) source such as CuI. There is an alternative, copper thiophene carboxylate (CuTC) is good to use in organic solvents and typically works really well. Typically we heat to 100 oC for about 30 mins to get a decent reaction using a 10 mol% catalyst loading.
Dear Mohamed
A link of paper on: CuI/l-Proline-Catalyzed Coupling Reactions of Aryl Halides with Activated Methylene Compounds is shown below:
https://www.google.com.eg/url?sa=t&rct=j&q=&esrc=s&source=web&cd=7&cad=rja&uact=8&ved=0ahUKEwjOv5L3ttfOAhXIthoKHX02CjYQFghJMAY&url=http%3A%2F%2Fpubs.acs.org%2Fdoi%2Fabs%2F10.1021%2Fol0518838&usg=AFQjCNFKbyTMrLlP_HWGXS6bWaepE2FARQ&sig2=AxcUkBcBom7cVwyAzcKy-Q
Dear Mohamed,
Please, find in attach, a paper on: L-Proline catalyzed one-step synthesis of 4,5-diaryl-2H-1,2,3-triazoles from heteroaryl cyanostilbenes via [3+2] cycloaddition
of azide.
Best wishes
Dear Mohamed,
Please, find in attach, an article on: Click Chemistry: Diverse Chemical Function from a Few Good Reactions
Hartmuth C. Kolb, M. G. Finn, and K. Barry Sharpless*
Dear Mohamed,
Please, find in attach, an article on:The click concept
Best wishes
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