Sample dissolved in both water and methanol or any other polar organic solvent. Direct injection to MS instead of going through LC column.
Sure, if the sample is homogeneous and particle-free. It's called direct flow injection. Don't forget to adjust the temperature and gas settings to a small flow rate. You may have to adjust the sprayer needle, also. Good luck!
Direct flow injection is a common and useful practice for pure sample but LCMS stays the better solution when a solution contains several compounds.
Hello, yes as said above is possible, but you have to take in account some things, for example if you want to check or not que chemical diversity of your sample (mixture?) or is for determination of the exact mass of one pure compound... also is very very important to make a blank measure (the same solvent used to dissolve your sample) to check the background and then you can be sure which peaks correspond to you sample.
Cheers!
Your matrix effects and ion suppression can have a big effect. If you have done a good clean up, or if the matrix is fairly pure then go ahead. For a more complex matrix a short chromatography run may lead to a significant improvement, especially if this is intended as an ongoing method rather than a short term method
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