I am afraid if STZ would induce DM without high fat diet (usually 40-50% Lard). The usual dose of STZ is 45mg/kg i.p.

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I am afraid you can't. I tried to induce type 2 diabetes with STZ and NA and the result was either normal rats or type 1 diabetes, depending on the relative doses of the two substances. You can induce type 2 diabetes either by using STZ with weeks of consumption of a high fat diet or by using genetically modified animals in special premises of course,

Yes. We can induce Type II diabetes by Steptozotocin on the animals fed a normal diet without excessive fat in the diet.

Hereby you can find the reference you are interested in, which verifies my opinion

The animal models of type 2 diabetes can be obtained either spontaneously or induced by chemicals or dietary or surgical manipulations and/or by combination thereof. The usual dose of Streptozotocin is 65mg/kg i.p.

Actually we induced insulin resistance by fructose other wise streptozotocin can easily developed type 2 diabetes

what is the dose of stz with high fat diet ??

and what is the duration of high fat diet??

A model of type 2 diabetes can be induced in rats by either i.v. (tail vein) or i.p. treatment with STZ in the first days of life. At 8–10 weeks of age and thereafter, rats neonatally treated with STZ manifest mild basal hyperglycemia, an impaired response to the glucose tolerance test, and a loss of pancreatic -cell sensitivity to glucose. It has been observed that STZ at first abolished the pancreatic -cell response to glucose, but a temporary return of responsiveness appears which is followed by its permanent loss.

It is well known that Steptozotocin can cause damage to the beta cells. if beta cells are damaged than the inhibition or supression of glucagon by insulin is "null'. So the cause could be the excessive secretion of glucagon. On the other hand, if a person or rat has high levels of insulin leading to insulin resistance then not only the cells of the liver and skeletal muscle become insulin resistant, but also the alpha cells become insulin resistant thus, leading to increase secretion of glucagon as well. Both will cause the effect of high blood sugars in the body.

Inside this article you can find the answers of your questions.

yes you can induce type 2 without high fat diet unless you want to measure other parameters or study them

how without high fat diet??

i injected 2 rats with 35 and 40mg/kg ,,, both diet on the 5th day !

the STZ would induce DM with high fat diet. The usual dose of STZ is 45mg/kg

DMt2 can not be caused by streptozotocin only it is necessary to add the agent cause insulinoresistance as a hyper fat or high fructose diet

Using STZ to induce type 2 is unconvincing , STZ is a drug target the beta-cells.

Yes, STZ would target beta cells in inducing type 2 diabetes like condition without high fat or fructose diet.

yea, can be induce by STZ alone but to conferim it fat diet or nicotinamid

Yes, you can be

The STZ can induce DM type 2 with high fat diet with a period 3-4 weeks