Neha Agarwal

Encapsulation is carried out with the aim of transferring the drug into the hydrophilic environment of blood and lymph. Otherwise they will not get into the cell. A hydrophilic drug dissolves in aqueous hydrophilic media and does not require encapsulation. If a person needs to take medications together, he can first take the encapsulated hydrophobic drug and then the hydrophilic drug, or swallow them together.

Hydrophilic drugs cannot be embedded into hydrophobic polymers due to their weak interactions

Of course Yes! By and large, hydrophobic polymers are used to load both hydrophobic and hydrophilic drugs. These polymers have properties that make them versatile for encapsulating various types of drugs. For hydrophilic drugs, the hydrophobic polymers can be used by integrating them through various methods like emulsification or forming complexes. Some hydrophobic polymers, when used in combination with surfactants or through specific formulation techniques, can create structures that allow the encapsulation of hydrophilic drugs within their matrices or shells. Polymers like poly(lactic-co-glycolic acid) (PLGA), polyethylene glycol (PEG), or polyvinylpyrrolidone (PVP) are often employed in drug delivery systems due to their ability to encapsulate both hydrophobic and hydrophilic substances. The choice of polymer and formulation technique would depend on the specific properties of the drugs being loaded, the desired release profile, and the intended application of the drug delivery system.@ Neha Agarwal..

Yes, surfactant and polymer based micelles are able to encapsulate hydrophobic and hydrophilic drug together. But they surfactant or polymer surfactant conjugates must have property like diblock or triblock polymers ie., PCL-PEG-PCL, and PLA-PEG etc.