Based on current research we know its is possible for paclitaxel to bind to MD2; a component of TLR4, and initiate TLR4 signalling pathways, but can docetaxel? I found some conflicting publications that would suggest that it can and others that say it cannot. Can anyone shed some light on this?
I THINK THIS SUMMARY MAY HELP YOU
LPS is the primary ligand of Toll-like receptor 4, activating it through binding to its accessory protein MD-2. Murine but not human cells expressing MD-2/TLR4 are also activated by paclitaxel. Paclitaxel binds to human MD-2. The binding site of paclitaxel overlaps with the binding site of bis-ANS and LPS, which results in the ability of taxanes to inhibit LPS signaling in the system with human receptors. Circular dichroic spectra of human MD-2 indicated differences in the chemical environment in the presence of paclitaxel and docetaxel. Molecular docking identified the interacting residues of MD-2 and suggests that hydrophobic interactions govern the binding, while the C-3'N group where the paclitaxel and docetaxel differ is exposed on the surface of MD-2.
Thanks for your help. Can you recommend a paper so I can read up on this?
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