Can anyone tell me if normal cardiac cells express Nrf2 (the master controller of cellular antioxidant stress) under normal conditions?

13 August 2014 1 9K Report

Nrf2 expression in cardiomyocytes.

Nrf2 is certainly expressed in the heart under normal conditions and some studies have shown that it is upregulated during stress conditions like cardiac hypertrophy. In fact, upregulation of Nrf2 is cardioprotective (Arterioscler Thromb Vasc Biol. 2009;29:1843-1850, Cardiovascular Research (2009) 83 , 354 – 361, Cardiovasc Res (2011) 90 (2): 315-324)

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