I am currently working on Self-Microemulsifying Drug delivery system of poorly water soluble drug etoposide in this research topic i am facing problem in etoposide solubility in oil / oily vehicle. I have used oleic acid , isopropyl myristate, castor oil, and some other oils but I have not found enough solubility of etoposide in different oils. Please can you help me in selecting suitable oil /oily vehicle
second question is that. is this necessary that we load therapeutic dose in SMEDDS formulation? etoposide dose is 25 to 100mg
the choice will be easier if you use the oils depending upon the solubility of the drug.... there is a lot of research going on on etoposides you can consult the literature
but i am unable to load single therapeutic dose of etoposide in SMEDDS
are you using natural oils..... if yes then go to synthetic one specially short chain or medium chain .,...... they will surely show good solubility......
Solid formulation for oral delivery of pH-sensitive, scarcely water-soluble etoposide are available. These are prepared after grinding the drug with a cross-linked polymeric carrier (crospovidone) under controlled process conditions (mechano-physical drug activation), and subsequently incorporating selected oil/surfactant (o/s) blends into the polymer particles. Physicochemical characterization (thermal analysis, drug dissolution kinetics, drug o/w partition studies) are done for on drug-polymer interaction at the solid state, and on the formulation performance in vitro, This results in the enhancement and modification of the etoposide solubilization process.
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