I have observed IFN-gamma induced growth inhibition in few of my cancer cancer cell lines. I assume that is due to the activation of STAT1 phosphorylation which in turn is targeting some downstream effectors of cell cycle arrest. To understand the exact mechanism, I want to inhibit STAT1 phosphorylation without interrupting the cell proliferation. Can you suggest any pharmacological inhibitor which will not kill or toxic to the cells itself?

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