How to determine the stability of Radiolabeled APIs?
I want to know about Selective separation of secondary amine from a mixture of primary and tertiary amine of long chain carbon atoms having high boiling points (boiling point range is 200 to 280oC
06 July 2018 9,916 0 View
I want to immobilize Nitrile hydatase which is in isolated form to convert Nitrile to Amide.
02 March 2017 6,434 7 View
I am looking a practical method of biocatalytic oxidation of octanol to octanoic acid, so I want some practical biocatalysis methods which will be efficient for large scale synthesis as well.
10 November 2015 501 2 View
The reaction carried out in aqueous condition, after completion of the reaction diluting the reaction mass with water, and also tried with basic work up, but crucial is that there is a base...
04 May 2015 8,084 3 View
We are busy in oxidation of a long chain aliphatic alcohol to acid by H2O2 with catalytic quantity of Na2WO4. 2H2O and PTC (Tricaprylmethylammonium chloride), but we could not see...
04 May 2015 3,094 5 View
We have required a chemical ‘N-formyl-N-methylformamide’ for a specific API . We haven’t found any supplier who can supply this chemical to us in our region. Can anyone inform the name of supplier...
09 October 2014 746 3 View
Hello, Why do i see this baseline drift when i compare my blank (black) to the sample (blue)? Any suggestions as to why this happened? Thank you!
11 August 2024 3,770 4 View
I'm currently working on calculating the collision cross section (CCS) for various ions, and I'm facing challenges when dealing with sodiated and multiply charged ions. Most of the resources I’ve...
08 August 2024 8,329 0 View
I am currently working on LncRNA; to know the lncRNA-protein interactions I want to do RNA pull down assay, so I need to design primers with T7 promoter. I need assistance in this regard.
07 August 2024 6,622 1 View
Hi all! My thesis groupmates and I are working on purifying an E. coli bacteriophage. The phage was handed down to us by the previous thesis group, but they only managed to purify it to about...
06 August 2024 5,801 4 View
I am currently working on a project involving liposomes and need to determine the maximum volume of siRNA that can be added to a 2.5 mL liposome solution with a total lipid concentration of 10...
30 July 2024 6,420 1 View
Can an analytical method's limit of quantification (LOQ) be outside its linear dynamic range, or is it always required to be within it? Please provide a thorough explanation supported by verified...
29 July 2024 7,198 9 View
I am doing research on wear mechanism of the additive manufactured metal parts under dry condition. Please share the reference to start the analytical modelling of the wear prediction.
29 July 2024 6,115 0 View
I am preparing a radiolabeled product using a radiolabeled substrate. I have the cpm values for different dilutions of both my known substrate and unknown product ? How can one determine the...
27 July 2024 3,604 1 View
Dear Siesta Users, I installed Siesta 5.0.1 and I want to use Grimme's D3 correction. According to the 5.0.1 manual, I could use a few parameters to include the D3 correction in the...
27 July 2024 5,748 0 View
It has been long known that EDC carbodiimide and NHS easter's half life agains hydrolysis are highly related to pH. However, very surprisingly, not yet found a paper giving a table/chart of their...
25 July 2024 8,738 0 View
