Can anyone help with information regarding an animal model (e.g. rats) for congestive heart failure?

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Chad D. Touchberry

Most people give an MI via left coronary ligation, or use ascending aortic constriction. On the other side are easier models that are more costly to maintain - Dahl Salt Sensitive rats, or a model of spontaneously hypertensive heart failure prone rats.

http://www.hindawi.com/journals/bmri/2011/497841/

Michaela Yakubovich-Dirks

Thank you Chad! I will explore the matter according to your suggestion! Warmest regards, Michaela

Darach O h-Ici

Another option for Rats is to use a model of Autoimmune Myocarditis. The animals develop a cardiomyopathy which provides a reasonable model for DCM in humans.

http://onlinelibrary.wiley.com/doi/10.1111/apha.12227/full

Andreas Brodehl

ligate the LAD? Maybe you can ask Prof. Dr. Steinhoff (http://www.med.uni-rostock.de/index.php?id=802). I know that his group is doing such experiments in mice in Rostock. It is not far away from Berlin.

Thanks Andreas, it is indeed a good idea:))) BR

Dear Ali

thank you for your valuable comments as well as for the links, br michaela