I have a basic doubt regarding reporting of odds ratio. We see that odds ratio can be expressed both in terms of risk (>1) or protection (1) to other (
Thank you for your response @Derek, I am analyzing an association of a duplication polymorphism with the incidence of an adverse effect to a drug. The scenario is the wild allele (non-duplicated allele freq:0.35) is less prevalent than the long allele (duplicated allele freq:0.65). It is referred as wild allele, since that was ancestral. If i report using the wild allele as reference, then I am finding odds ratio for long allele greater than one. But if i consider the major allele, then I should use the long allele as reference, in that case, the odds ratio for short (wild) allele is less than one. I was just thinking how to present the data.
Thank you @Derek. another issue i met was with power calculation. The power calculation requires the risk allele frequency. Sometimes it is said minor allele frequency. This is not an issue under normal conditions because, most cases the risk allele will be the polymorphic allele and not wild allele. But in my case its not same, so I am confused if i should use the risk allele (long allele) or the minor allele (wild allele).
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