Can anyone help me in the insilico analysis of PK/PD parameters in the binding of drug(normal and engineered) and protein?
Dear Researchers, Is it feasible to distinguish between alpha and alpha prime martensite in the Ti6Al4V alloy under rapid solidification in the as-cast state using XRD, in addition to...
30 July 2024 3,849 0 View
through origin software
17 July 2024 4,991 0 View
please suggest the research paper related to the instrument is used in it.
16 July 2024 8,453 1 View
Is it possible to differentiate or calculate, the amount of ferromagnetic and antiferromagnetic contribution in a canted system? (Weakly frustrated canted antiferromagnetic system)
25 June 2024 6,210 0 View
In many papers, they have given the atomic position, lattice parameters, bond length, bond angle etc. values with (). what is the value of inside the bracket? If it is error bar how to find in...
13 June 2024 7,607 2 View
As part of my thesis I'll be conducting a single-sample pre-post intervention analysis, in which my only DV is ordinal (7-point Likert scale). In my research proposal I said that I would use...
05 June 2024 3,122 2 View
Snowball metrics is used by scival.com to report some performance indicators. This metrics seems rather obscure from the mathematical standpoint. Unfortunately there is apparently (after a quick...
05 June 2024 7,463 0 View
Menurut Bapak/Ibu, apakah editor jurnal lebih memilih Systematic Literature Review 10-20 tahun daripada yang menelaah 5 tahun? In your opinion (Mr and Ms), what do you think, journal editors...
26 May 2024 140 2 View
I am preparing a case study of a social work professional organisation which is non-existent now but had a glorious past. For this, I interviewed around 20 members of the association to understand...
18 May 2024 6,656 3 View
Tree growth is an important aspect of forestry and forest ecology. Typically a growth rate is calculated as the difference between two stem diameter measurements over a given time interval: (dbh2...
15 May 2024 8,739 2 View
Hello, I have 5 blood samples each from 6 patients treated with a drug: on day 1 (before treatment), 7, 14, 21 and 30. In these samples I have measurement of both the drug concentrations and...
06 March 2024 6,595 2 View
Hey Folks, I am trying to install PK solver ad-in on a Mac with MS Excel 365 (64bit Version) (https://www.sciencedirect.com/science/article/abs/pii/S0169260710000209?via%3Dihub). However, I...
18 July 2023 6,743 4 View
Is it possible for a drug that it's duration of action time be bigger than it's clearance time?
17 January 2023 677 4 View
I am working on a development project for ELISA using human sample pools and a newly developed antibody drug. In this assay we use one set of QCs containing ULOQ,HQC, MQC, LQC, LLOQ. And a sets of...
24 January 2022 4,780 2 View
Trying to understand the relationship between t1/2 and dosing regimen (qd, bid, tid, ...). Are dosing frequencies for a drug approved based on t1/2 or other factor like AUC..etc? where can such...
13 December 2020 5,780 5 View
The drugs in question are mostly chronic maintenance drugs with PO, topical, ophthalmic and tube feeding route. What parameters determine dose intervals?
16 November 2020 10,172 3 View
I can fathom the idea of PK being different b/w dogs and rodents, but why would I be seeing a significantly different PK profile for the same drug tested on rats and mice?
10 September 2020 8,966 5 View
I have two types of data, one is 200 drugs' plasma concentrations, another is the binding affinity(Ki, Kd or IC50) between drug and its targets downloaded in Chembl database. Now I want...
10 March 2020 2,251 3 View
An anesthesiologist using a TCI system to administer an IV agent is able to set and change a target concentration, basing the choice of target concentration on observation of clinical effect....
21 April 2019 3,514 2 View
Can any one provide me a standard PK/PD protocol . for small molecule/ peptide?
31 December 2018 5,876 5 View