In a human heart according to the increase in the developmental stage, the heart tissue stiffness (Extra cellular matrix stiffness) goes on increasing. Has anyone checked the human heart tissue stiffness? Can anyone give some ideas about it?
Dear Ravindra,
A sensitive method for detecting Heart stiffness is by assessing stress-strain relationships. Utilizing pressure-volume relationships, the elastic stiffness may be evaluated in patients with normal ventricles, inappropriate hypertrophy, and congestive cardiomyopathy
Thanks Anil for your valuable answer. Is there any data suggesting what is the exact stiffness (Modulus of elasticity) in normal and hypertrophic ventricles in human?
Ravindra,
You probably find hundreds of papers on this issue if you search the keyword: diastolic dysfunction.
Ravindra,
If you are still looking for additional answers to your question, please, check the recent publication from Young JL et al: Mechanosensitive Kinases Regulate Stiffness-Induced Cardiomyocyte Maturation, SCIENTIFIC REPORTS, vol. 4 : 6425, DOI: 10.1038/srep06425.
An excerpt from this paper says: ”… the heart does not begin as a contractile, 10 kPa ECM but instead originates from much softer mesoderm where stiffness is less than 500 Pa and stiffens up to 10 kPa by embryonic day 14 with a t1/2=60 hr.”
I hope, this helps.
Best, Tomo
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