Such a protocol will afford me the opportunity of getting a model that connects environmental pollution with neurodegeneration and help to further study the basic events in neurodegeneration.
I am terrible sorry I do not know about it. But any enviremental couse is hardly improved.
Best,ű
Judit Málly
Dear Oulgbenga,
Could you specify the model you want to use (in vivo) or in vitro? Do you want to stidy neurodegeneration inrelation to environnemental injury or alone?
Manganese, at certain concs can induce neurodegeneration in a version that mimics Parkinson's disease.
One common model to study toxic demyelination in MS is the Cuprizone model. Here is one reference (http://www.ncbi.nlm.nih.gov/pubmed/18439226).
Cuprizone is a copper chelator.
A few colleagues and I recently wrote an article on the topic, specifically on Mn, Hg, and Pb. You will find it on my ResearchGate page (last of the highlighted publications). I am glad you are interested in the topic. I think it has been neglected for too long!
lead could be used to generate neurodegenerative state in brain. See the references below:
- Bihaqi SW, Bahmani A, Subaiea GM, ZawiaNH.Infantile exposure to lead and late-age cognitive decline: Relevance to AD.Alzheimers Dement. doi:pii: S1552-5260(13)00131-3. 10.1016/j.jalz.2013.02.012. [Epub ahead of print]
-Bihaqi SW, ZawiaNH.Enhanced taupathy and AD-like pathology in aged primate brains decades after infantile exposure to lead (Pb).Neurotoxicology. 39:95-101, 2013.
-Dosunmu, R, Alashwal, H, Zawia, NH. Genome-wide expression and methylation profiling in the aged rodent brain due to early-life Pb exposure and its relevance to aging. Mech Ageing Dev. 2012 May 18. [Epub ahead of print]
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