Can anyone convert the eluent ratio of Acetone/HX to EA/HX?

29 April 2014 1 4K Report

One of my reaction procedures used the eluent system of Acetone and Hexane for their column chromatography. (They used Acetone/HX = 1/30)

But I usually use EA/HX or Ether/HX system in the lab.

Can anyone convert or at least approximate the ratio?

Amin Bornadel

Both acetone and EA are polar aprotic solvents and it should be possible to replace acetone with EA. Dipole moment of acetone is 2.88 D and for EA is 1.78 D. Dielectric constant of acetone is 21 and for EA is 6. I would start with EA:Hex 1:10 and change accordingly.

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