I am doing the HLA-typing by NGS before starting the same I need to understand what the HLA-typing is and about the nomenclature aspects. I have not found any articles which give me complete details of the same. Could anyone suggest an article which explains the nomenclature completely it will be of great help.
HLA –A*02 : 101 : 01 : 02 N
a b c d e
a-which gene the allele is a modification of.
b- what antigen type that particular allele is, which typically signifies the serological antigen present.
c-what protein the allele codes for and numbered sequentially in order they are discovered.
d-Indicates an allele variant that has a different DNA sequence but produces the same protein as a normal gene.
e- Designate a single or multiple nucleotide polymorphism in a non-coding region of the gene.
Here is a useful article:
http://www.bloodjournal.org/content/118/23/e180?sso-checked=true
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