I am going to develop a method for Risperidone plasma concentration measurement using HPLC-UV method. I have tried to develop a method for it but i cant get the good reference for it
Other than LLE, mixed mode of cation exchange + non-polar phase SPE is also great for extracting risperidone and 9-OH-risperidone from plasma. 7-Met-risperidone was employed as internal standard. Good luck!
Sensitive Method for the Quantitative Determination of Risperidone in Tablet Dosage Form by High-Performance Liquid Chromatography Using Chlordiazepoxide as Internal Standard.