I have been having some difficulty in understanding the OASIS-3 (Open Access Series of Imaging Studies) database for neuroimaging datasets for cognitively normal and cognitively declining patients (e.g., Alzheimer's disease). There are several respondents who received a "Cognitively Normal" remark for the first diagnosis, while having various remarks for the second diagnosis, particularly: Active/Remote Mood Disorder, Remote Hypothyroidism, Active Bereavement, and Active Alcoholism. Can these "disorders" or "impairments" be classified under Mild Cognitive Impairment (MCI) to eventually lead to Alzheimer's disease or other decline/change in cognitive performance?
https://www.alz.org/alzheimers-dementia/what-is-dementia/related_conditions/mild-cognitive-impairment
https://www.alz.org/research/for_researchers/diagnostic-criteria-guidelines
MCI has two types, amnestic and nonamnestic (first ref above). The diagnostic criteria and guidelines are available (second ref). There are other resources you could explore. Good luck.
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