Can 5-aminolevulinic acid hydrochloride be used instead of 5 - Aminolevulinic acid ?

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Why the second reaction of my synthesis is not completing/working acc to TLC despite following a published method ?

Dear researchers, For the first rxn, I performed Claisen Schmidt condensation reaction to form an animated- diarylpentadienone product in cold conditions by dissolving aminoacetophenone in...

01 November 2023 2,959 5 View

How to split the huge ligand file from database into separate ligand files for molecular docking?

Hi researchers, I have downloaded 20,000 compounds from databases in .sdf format in a single file (size: 108 GB). Could someone guide me on splitting the enormous single ligand file into...

15 February 2023 6,063 9 View

How to recrystallize an oily compound after column chromatography ?

Hi researchers, I am currently synthesizing sulfonamide compounds by reacting aminoacetophenone with cinnamaldehyde using 6M NaOH (catalyst) and aqueous ethanol (solvent) at room temperature...

08 September 2022 4,640 7 View

Can anyone guide me on how to view the dssp secondary structure analysis generated by AMBER CPPTRAJ using gnuplot?

Hi researchers, I have used AMBER CPPTRAJ to generate dssp.gnu to view the 2D secondary structure of my protein throughout the molecular dynamic simulation using Gnuplot software....

18 May 2022 3,205 3 View

How to visualize the results generated from the analysis of MD trajectory using Cpptraj in AMBER16 ?

Hi researchers, I have used Amber16 to run a molecular dynamics simulation of my protein system for 50 ns. After the production run was completed, I have generated an MD trajectory with 2500...

23 March 2022 4,986 1 View

How to do shifting in residue numbering in Amber 16 to my topology files prmtop and rst7 ?

Hi, researchers, Kindly please guide me on how ambpdb from AmberTools which has the flag "-offset" can allow shifting in residue numbering? I tried but the amber doesn't recognise the flag...

08 June 2021 6,170 2 View

Which software or programme is suitable to be used to generate parameter for ligand that has Fe atom ?

Hi Researchers, I'm currently trying to generate parameters for the ligand and heme group that bind/crystallised with the protein structure. I need to know, which software or programme is the...

14 May 2021 3,185 8 View

How to choose the right files to be used as topology and coordinate file for amber ?

I have used ATB 3.0 software to generate parameters for my ligand and heme group molecules to prepare them for molecular dynamic simulation using Amber version 16 in Linux. However, I found there...

10 May 2021 8,112 2 View

Why I faced this error while using Antechamber in Amber 16 to generate parameters for my ligand that co-crystallized in protein ?

When I'm trying to use the antechamber in amber version 16, I couldn't proceed using it to generate parameters, topology and coordinate files as I got this type of error. The error mentioning...

10 May 2021 1,712 3 View

Does minimization require for average pdb structure extracted from 2drms plot using CPPTRAJ AMBER 16

Hi researcher, I'm really looking for your guidance and help in order for me to pursue my next step in computational work. I'm new to computational work and keen to learn more. Currently, I'm...

01 January 1970 6,894 2 View

Separation of organic acids-HPLC?

Hello What should be done to separate and identify organic acids in HPC when their RetTime is the same?Like oxalic acid with Propanoic Acid.or acids that have a very close RetTime.

07 August 2024 8,782 3 View

The aqueous fraction of the hydroethanolic extract is showing the presence of palmitic acid. What is the mechanism responsible ?

Palmitic acid presence in aqueous fraction

05 August 2024 8,622 4 View

How to convert g/kg Humic acid dose to kg/ha?

I used humic acid at 0.044 g/kg soil in my pot experiment. But finally, I have to recommend kg/ha. Each pot's soil weight was 11 kg. What is the solution?

02 August 2024 7,185 6 View

Inquiry on Maximum Nucleic Acid Volume for 2.5 mL Liposome Solution?

I am currently working on a project involving liposomes and need to determine the maximum volume of siRNA that can be added to a 2.5 mL liposome solution with a total lipid concentration of 10...

30 July 2024 6,418 1 View

Why is trifluoroacetic acid (TFA) used in c-18 column?

I would like to know the role of the TFA (trifluoroacetic acid) used on reverse phase chromatography c-18 column. It's is often used with a concentration of 0.1% on the mobile phase.

23 July 2024 8,073 3 View

Can we add calcium carbonate to any media as an indicator for lactic acid producing bacteria?

As mentioned in literature the addition of CaCO3 to MRS Agar media is considered as an indicator for lactic acid producing bacteria, so I wonder if we can add CaCO3 calcium carbonate to any other...

20 July 2024 7,504 0 View

What is the suitable solvent of MIL-100 for chemotherapy?

I synthesised a nanocarrier by conjugation MOF (MIL-100) with folic acid for use in chemotherapy but the samples didn't dissolve completely in aqueous solution or DMSO. Instead, they only...

19 July 2024 8,522 0 View

Can I use candle-jar technique to lactic acid bacteria?

I don't have the anaerobic generators (Anaeropac) so I'd like to try the candle-jar tecnique for the cultive of lactic acid bacteria

15 July 2024 8,890 2 View

What is the suitable solvent of MIL-100 for chemotherapy?

I synthesised a nanocarrier by conjugation MOF (MIL-100) with folic acid for use in chemotherapy but the samples didn't dissolve completely in aqueous solution or DMSO. Instead, they only...

15 July 2024 2,414 1 View

Should all lactic acid bacteria be catalase negative? should all probiotic bacteria be catalase negative?

I am working on probiotic bacteria for fish, and I am trying to isolate probiotic bacteria like lactic acid bacteria or other probiotics from the gastrointestinal tract of fish using different...

12 July 2024 3,755 4 View