In theoretical reply of this question is no, but you can check using different blocking agent like along with BSA in ELISA to check interference with sample.

It would not be advisable. Use a protein-free blocking agent instead, to be sure that there are no antibodies. These reagents are commercially available.

Thank you Awadh and Adam.

Since you are screening for antibodies in cattle serum, it essential to avoid bovine serum albumin as a blocking agent. You can try a number of other blocking agents ideally such as protein-free blocking agents as Dr. Adam B Shapiro suggested.