After botox for wrinkles is it possible to extend duration of botox for a longer period by any retarders in metabolism?
duration of the botox varies according to several factors
patient muscles
area
dose
frequency of injection
Satyaprasad,
The above mentioned factors that Islam pointed out are important in the duration of botulinum toxin. The reason that the effect of botox wears off in that amount of time is because the presynaptic terminals recover function.
However, there is some findings that suggest Zytase (zinc and the enzyme phytase) can prolong the life of Botox. This is because zinc is required for botox to work effectively. After all, Botulinum toxin A is zinc matrix metalloprotease. Below is a paper about the study that showed the efficacy of zinc/phytase supplementation.
Reference
http://www.nhs.uk/news/2012/09September/Pages/botox-pill-zytaze-claims.aspx
http://www.ncbi.nlm.nih.gov/pubmed/22453589
I find that the less muscles you inject the longer duration of action and this is not always dose dependant
How longer duration with less muscle injection and especially in men who doses should be more Khalid Mohamed.
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