There is an informative new paper written by Mark Zimmerman on the relationship between bipolar disorder and BPD. Full-text version can be found here:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811087/
You can see our abstract about TRIPOLAR AFFECTIVE DISORDERS on RG site.
Some suggest that Bipolar II and Boder line personality disorder has overlap.
Dear Imran
and to all of you following this question?
I am sure that we can accept this. But what do we know about the neurobiological, genetic mechanisms of this overlap?
best greetings
Egon
I am uncertain what the overlap may be, neurobiologically, but I found a differentiation:
http://www.sciencedirect.com/science/article/pii/S1053811914003425
The overlap could be located in how the functional network connectivity functions differently from one another. Even the differences are telling, in that, there is an seeming abnormality.
Another article (which is only about bipolar disorder):
http://ww1.cpa-apc.org/publications/archives/cjp/2002/march/inReviewBipolar.pdf
studied many different enzymes and proteins in signal transduction. Perhaps there could be an overlap here as well. Yet, I did not find as an extensive study on this when it came to BPD.
Not as much has been done for BPD, it seems. Yet, I could be totally wrong.
Hope this helped a little bit.
Good luck to you!!!
Hi Egon
In clinical diagnosis, some of criterias in (BMD and BPD) both disorders are same, such as emotional instability, tendency to self harm, inclind to implementing risky decision, ambiguity in identity, switch in mood due to strees driven situations, hyperactivity in sexual drive and so on. This same conditions have a same biological, mental, and past history in family and life span. But personality disorders as BPD have a longterm patterns of cognition, emotion, and behaviour, unlike to BMD.
Hi Omid,
By "But personality disorders as BPD have a longterm patterns of cognition, emotion, and behaviour, unlike to BMD." what do you mean? I was wondering if you meant these longterm patterns are always present in a person with BPD, while with BMD the patterns are like hiccups (episodic).
I am not sure what you mean by "personality disorders...have a longterm patterns of cognition, emotion, and behaviour, unlike to BMD"
I only know in my experience, with bipolar disorder the illness does not begin to manifest until the teenage years and classically a bipolar subject runs amok in their early thirties. Episodes are induced by stress and are susceptible to treatment with prescription drugs.
I understand that with BPD prescription drugs are ineffective.
The treatments for these two conditions have little resemblance.
Simply because two conditions appear to have qualities that overlap does not mean that they are connected at the molecular level.
I can't understand why these conditions would necessarily be either co-morbid or spectrum based on the treatment criteria. Moreover it occurs to me that bipolar I has more commonality with BPD than bipolar II.
I must admit I know very little about BPD, but my intuitive sense tells me that BPD and BMD probably have little in common other than exacerbation by chaotic environments from early on.
Hi Margaret
Both disorders haven't same in episode. BMD is episodic but BPD is longterm patt.
In many of BPD cases, thay can experience mood switch but it's duration is shorter than BMD. Either BMD type 1 or 2 can occur in expierence duration of BPD. Medication for both conditions have evidances in the light of it's efficacy. I have seen for many patients with BPD, psychiatrists prescript mood stabilizers and antidepressants. These show same biological and mental mechanism.
Dear all
Bipolar disorder patients have significantly higher prevalence of personality disorder than the general population. Bipolar patients with personality psychopathology have poorer response to medications and a more virulent course of illness. Across studies approximately 10 % of patients with Boder-Line personality Disorder had bipolar I disorder and another 10 % had bipolar II disorder (Zimmermann et al (2013). This raises the question whether they may be independent or interdependent (comorbidity or spectrum). Do they have different neurobiological parameters in cortical activity, glucocorticoid receptor sensitivity, and mitochondrial dysfunction, genetic linkages, limbic modulation and do they differ with respect to affective dysregulation, psychotic episodes etc.
Fan AH, Hassell J. (2008). Bipolar disorder and comorbid personality psychopathology: a review of the literature. J Clin Psychiatry.;69(11):1794-803.:
Zimmerman M, Morgan TA. (2013). Problematic boundaries in the diagnosis of bipolar disorder: the interface with borderline personality disorder. Curr Psychiatry Rep.;15(12):422.:
You can see my articel - summary about Tripolar affective disorders on RG.
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