Joel Cracraft listed 7 big questions of systematic biology (ANN. MISSOURI BOT. GARD. 89: 127–144. 2002.).
1. Wat is a species?
2. How many species are there?
3. What is the tree of life?
4. What has been the history of character transformation?
5. Where are earth's species distributed?
6. How have species distributions changed over time?
7. How is phylogenetic history predictive?
In the great era of new technology and large data including omics, the integrative approach might help to solve some more questions.
What big questions of systematic biology are in your top list of challenge? Any inputs with some references are warmly welcome.
Systematic Biology Forum, China