Between the 2000 Malvern Mastersizer and 3000 Malvern Mastersizer prticle size analyzer which one is more suitable and advantageous to validate particle size analysis method or for paticle size analysis of drug substance ?
3000 Malvern Mastersizer prticle size is more precise than 2000 model old model @
Your question, as stated, hides a great controversy, I am sorry to say. Both size analyzers you mention are very capable, and very consistent. However, neither take particle “shape“ into account. Therefore, particle “size” is a very relative thing. Without an understanding of the shape of your particles, there can be differences in outcome between any two types of size analyzers. “Size and shape“ analysis would require an instrument that can do size and shape analysis.
Let me explain in example: I am sorry to say this, but one can have “sphere” and “rod” shaped particles that can produce the exact same “size data,” when using size analysis only, but the two samples will look very different under microscope examination. This is a conundrum associated with “size-only analyzers.”
However, when considering only “size,” as long as the same analyzer is used for the analyses, which ever it is, you will be capable of making “size” comparisons between any two samples (that are roughly the same shape). Without “Shape” analysis, “size“ accuracy can only be held constant by using the exact same size analyzer every time. A given size analyzer instrument will maintain the same level of accuracy, the same analysis process and a consistent, reproducible result, because size analyzer will do the analysis exactly the same way every time, (if it is kept calibrated per instructions for that analyzer.)
It is seldom discussed, but “size“ analyzers generally consider every particle to be a sphere; a poor assumption in most cases. But, interestingly, this does not impact reproducibility for a given instrument.
Malvern 2000 is past and Malvern 3000 is present and future since the parent company had discontinued the Malvern 2000 instrument. you can develop a method on malvern 3000 so that you will get similar results on both instruments.
Boths models are capabale to analysed the particle size but Malvern 3000 is little advance so you can go with advance version
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