I am starting my work on a project which involves induction of Asthma in C57B6 mouse. And some WT and KOs. We don't have a robust model for Asthma induction, so I am trying to establish a protocol and a model for this process. My PI has suggested to work with HDM model instead of Ovalbumin model as this apparently is the closer to human cause of Asthma. So can someone with experience share from their experience any model which works the best for Asthma induction in Mouse model which is closer to the Human model of Asthma development. I would be grateful if someone could share some papers or links in this regard.
In order to support the development of new asthma treatments, our Gempharmatech platform has independently developed OVA-induced asthma mouse models and HDM-induced asthma mouse models. HDM-induced asthma model is a type 1 hypersensitivity model with Th2 signaling pathway activation, which can simulate the pathogenesis of asthma in real environment with long slow onset cycle.
Please Connect with me and detailed sharing of our model data with you^^
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