So far many papers (my literature study) are suggesting that Ultraviolet Radiation on TiO2 induces photocatalytic reaction which makes it give Bactericidal effects on gram positive and gram negative bacteria. Will TiO2 gives bactericidal effect against gram positive and gram negative bacteria without UV irradiation? Kindly suggest me what are gram positive and gram negative bacteria. When a TiO2 based material is implanted into body it does not have the photocatalytic effect inside the body UV light will not pass, then how TiO2 will give Bactericidal effects inside the body?
Please see the following for gram-negative and gram- positive bacteria differences, taken from Wikipedia.
Gram-positive bacteria take up the crystal violet stain used in the test, and then appear to be purple-coloured when seen through an optical microscope. This is because the thick peptidoglycan layer in the bacterial cell wall retains the stain after it is washed away from the rest of the sample, in the decolorization stage of the test.
Conversely, gram-negative bacteria cannot retain the violet stain after the decolorization step; alcohol used in this stage degrades the outer membrane of gram-negative cells, making the cell wall more porous and incapable of retaining the crystal violet stain. Their peptidoglycan layer is much thinner and sandwiched between an inner cell membrane and a bacterial outer membrane, causing them to take up the counterstain (safranin or fuchsine) and appear red or pink.
Despite their thicker peptidoglycan layer, gram-positive bacteria are more receptive to certain cell wall targeting antibiotics than gram-negative bacteria, due to the absence of the outer membrane.
TiO2, specially as NPs, has the capability of inactivation of microorganisms due to its strong oxidizing power by free radical generation, such as hydroxyl and superoxide anion radicals, showing reductions growth against several microorganisms. However, UV radiation is needed for TiO2 photocatalytic activity. It can show this activity, though less, by solar radiation.
@Mohammad Kooti Sir is there literature on TiO2 showing bactericidal effect without UV against both gram negative and positive bacteria
Dear Dinesh
Please check the following reference, you might find good information about the antibacterial activity of TiO2.
doi: 10.3390/ma13010078
Please follow this link
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981437/
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