Please I need your experience in understanding the role of Autophagy in Alzheimer's disease and if it could be a potential target for finding a cure for AD.
Stress to endoplasmic reticulum (ER) can cause UPR and aggresome formation. Aggressome accumulation has been shown in AD. The ER stress is also related to autophagy. So theoretically autophagy can be a target for AD treatment. The thing is when you start to study a new signaling pathway in a disease there is always some association. The issue becomes how to decipher your findings.
Dementia is a type of brain disorder that affects the daily performance of activities and contacts. Alzheimer's disease is a type of dementia that affects memory, language and thought. Although older people are affected by this disease, young people are also vulnerable to these diseases