Sweilem Baseem Al Rihani

6 Questions 20 Answers 0 Followers

Questions related from Sweilem Baseem Al Rihani

Autophagy as a potential target for Alzheimer's disease!

Please I need your experience in understanding the role of Autophagy in Alzheimer's disease and if it could be a potential target for finding a cure for AD.

07 July 2017 4,588 11 View

How to calculate the cumulative concentration in the basolateral compartment of caco2 cells?

I am doing an experiment where I am applying a drug 40 microMolar to the apical dissolved in HBSS (500mcl total), and no drug just 1.5 ml of HBSS to the basolateral and then I measure the...

14 March 2017 4,858 2 View

Aging and blood brain barrier dysfunction : What are the most significant findings to date?

I am trying to understand the relationship between the healthy aging process and the development of the blood brain barrier disruption which might lead to several neurodegenerative diseases such...

13 July 2016 1,422 7 View

Alzheimer's disease: What makes it that complicated to find a cure?

Since all the treatments that have been approved by the US Food and Drug Administration (FDA) for Alzheimer's. For example, cholinesterase inhibitors and memantine can help treat memory and...

14 February 2016 2,303 29 View

Can anyone suggest a good immunohistochemistry protocol to detect mouse IgG in the brain after injecting the mouse with Evans blue dye?

I need your help to optimize a protocol for the measurement of the BBB permeability by measuring Evans blue dye and mouse IgG in the brain! Thanks a lot

30 October 2015 6,798 4 View

What is the best transfection kit and protocol for transfecting murine neuronal cells (Neuro2A) with APP to produce amyloid beta?

Hi I am looking for a good protocol and kit for transfecting mice neuronal cells with the amyloid precursor protein APP in order to produce amyloid beta. I really appreciate your help and support.

08 September 2015 9,026 2 View