Question Are specific midlife to late-life longitudinal blood pressure patterns associated with increased risk of dementia among older adults?

Finding In this prospective cohort study that included 4761 participants with 24-year follow-up and blood pressure measurements at midlife and at late life, those with midlife and late-life hypertension (hazard ratio, 1.49) and those with midlife hypertension and late-life hypotension (hazard ratio, 1.62) had higher risk for incident dementia compared with those who remained normotensive.

Meaning Patterns of blood pressure in midlife and late life may be associated with differing risks for incident dementia.