The exact cause of Reye's syndrome is unknown, although several factors may play a role in its development. Reye's syndrome seems to be triggered by using aspirin to treat a viral illness or infection particularly influenza and chickenpox in children and teenagers who have an underlying fatty acid oxidation disorder.
Aspirin has been linked with Reye's syndrome, so use caution when giving aspirin to children or teenagers for fever or pain. Though aspirin is approved for use in children older than age 3, children and teenagers recovering from chickenpox or flu-like symptoms should never take aspirin.
Reye's syndrome: Aspirin as treatment in children and adults with COVID-19
Reye.s syndrome, although often blamed to be associated with Aspirin use in children, may be more related to age, viral infections, and genetic factors (1), and maybe Reye's-like syndrome (2), Although Aspirin should be avoided in treating any febrile illness in children aged less than 16 years, its use has many salutary effects beyond symptom control in adults with COVID-19 (3).
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