Can i know how to prepare incompatible pathogen of a particular race against a disease.
Extensive work on incompatibilité has been perforées on Cryphonectria (former Endothia) parasita exemple below.
Molecular characterization of vegetative incompatibility genes that restrict hypovirus transmission in the chestnut blight fungus Cryphonectria parasitica.Auteur(s):Choi, G. H.; Dawe, A. L.; Churbanov, A.; Smith, M. L.; Milgroom, M. G.; Nuss, D. L.Adresse:Institute for Bioscience and Biotechnology Research, University of Maryland, 9600 Gudelsky Dr., Rockville, MD 20850, USA.; [email protected]:Genetics 190 (1) Bethesda: Genetics Society of America,2012, 113-127Langue:EnglishPays de publication:USARésumé:Genetic nonself recognition systems such as vegetative incompatibility operate in many filamentous fungi to regulate hyphal fusion between genetically dissimilar individuals and to restrict the spread of virulence-attenuating mycoviruses that have potential for biological control of pathogenic fungi. We report here the use of a comparative genomics approach to identify seven candidate polymorphic genes associated with four vegetative incompatibility (vic) loci of the chestnut blight fungus Cryphonectria parasitica. Disruption of candidate alleles in one of two strains that were heteroallelic at vic2, vic6, or vic7 resulted in enhanced virus transmission, but did not prevent barrage formation associated with mycelial incompatibility. Detailed characterization of the vic6 locus revealed the involvement of nonallelic interactions between two tightly linked genes in barrage formation, heterokaryon formation, and asymmetric, gene-specific influences on virus transmission. The combined results establish molecular identities of genes associated with four C. parasitica vic loci and provide insights into how these recognition factors interact to trigger incompatibility and restrict virus transmission
You could have a look at the works on Fusarium oxysporum about vegetative compatibility groups. There are several papers, I suggest one of mine:
Bertoldo, C., Gilardi, G., Spadaro, D., Gullino, M.L., Garibaldi, A. - Genetic diversity and virulence of Italian strains of Fusarium oxysporum isolated from Eustoma grandiflorum
(2014) European Journal of Plant Pathology, 141 (1), pp. 83-97.
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