In the course of discussions of the question: «A funny question: bacteria in the brain; do they migrate thereto or originate therein?» at the RG pages (https://www.researchgate.net/post/A_funny_question_bacteria_in_the_brain_do_they_migrate_thereto_or_originate_therein ), it was first noted that, when considering the causes of the appearance of the microorganisms in brain, the possibility of their formation within the brain cells should not be excluded. The logic of this sentence was as follows. Because the formation of new neurons and, consequently, new DNAs in the brain cells is, at present, a well-known fact, free nucleotides and nucleosides occur within cells; therewith, side processes of formation of rather short foreign DNA-like molecules and their subsequent replication, seemingly, cannot be completely excluded. Such a sentence doesn't contradict the context of the Mitosis and Replication Hydrate Theory (MRH-Theory) developed by us.
If similar processes are really inherent in Nature, they would be of great importance for the general biology, medicine, and species diversity history.
Possible in other tissues but not inside brain because it is protected by BBB(Blood Brain Barrrier) layer.
Dear Manjur M Shah,
I think, you are right when writing about possibility of origination of parasitizing issues in the cells of tissues but you mistake when writing about impossibility of such a process within brain.
Indeed, the blood-brain barrier limits the transcapillary diffusion of the polar particles. However, the O2, CO2, and C6H12O6 diffusion is not limited on the scale on which it is necessary. The diffusivity of the brain capillaries is also confirmed by the mitosis of the brain cells; the last is slow, but it occurs and the slowness of this process should rather stimulate than block the process of formation of foreign DNAs within some cells if such a process exists really, because the time gives a possibility for increasing in sizes and functional ability for the foreign DNAs. The indubitable mitosis of the brain neurons shows that the diffusion of the nucleosides and N-bases and (it is terrible to think!) even nucleotides into the cellular protoplasm is possible. In any event, such processes, by no means seem to be impossible in the period preceding the birth of a foetus; meanwhile, the process of origination of foreign life, and not only microbial, within an organism that lives a rather long time could start even before its birth if such a process is principally possible, which, in my opinion, cannot be excluded. I allow myself to underline that the confirmation of the mechanism under consideration could explain a number of phenomena observable in living nature and would be rather useful for medicine and understanding of the species diversity. I underline especially that it is in the context of the Life Origination Hydrate Theory (LOH-Theory) and Mitosis and Replication Hydrate Theory (MRH Theory).
Dear Dr. Manjur M. Shah,
Thank you for your issue. It forced me to ponder once more on this problem. I understand that our common with Elena opinion on it is rather unexpected for the true experts, but discussions are necessary to understand the real causes of natural phenomena and it would be false to think that all widely-accepted today understandings of them are veritable and unbreakable.
There are theories that, for example, mitochondria in cells evolved from bacteria absorbed by these cells.
I invite you to the discussion.
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