X-ray has featured prominently in the diagnosis of the coronavirus disease. Are there MRI studies on this disease?
Sir, attached is an article from Radiology comparing CT and MRI features of a COVID-19 patient but the virus was not detected in the CSF. However, because of motion artifacts, MRI might not be considered as the main modality but as a complement to CT. Article COVID-19–associated Acute Hemorrhagic Necrotizing Encephalop...
@Dr. Opadele, many thanks for your kind response. The paper is quite compressed but informative. Don't you think motion-compensated MRI sequences could get around this challenge? Secondly, it is quite interesting that the virus was not detected in the CSF; do you think a relaxation (T1 and T2) profile could reveal some dynamics of the observed acute necrotizing hemorrhagic encephalopathy?
Dr. Michael Dada thank you for the questions, Sir.
1) The paper is more like a case report!
2) Yes, respiratory compensation, cardiac gating, and similar techniques can be used to minimize motion artifacts as you've mentioned. However, x-ray imaging might be the first modality of choice in this situation because of acquisition time, cost and the current indication of the patient. Recently, I saw increased ground-glass opacities in the chest CT of a patient that presented with the virus and thought that MRI could also be used for cross-comparison.
3) I think that signals from the weighted images of T1 and T2 images could further provide insights into the diagnosed condition. Also, I came across a different case report where the virus was confirmed in the CSF of a patient after gene sequencing was performed, probably because the central nervous system had been affected. This drew my attention to the first article stating that ' testing for the presence of SARSCoV-2 in the CSF was unable to be performed'. Therefore, I think that in diagnosing this disease, a single imaging modality might not be sufficient in understanding the underlying problems.
@Dr Opadele. Sir, I read your comments on MRI in a diqgnostic setting. Do you have an opinion on how MRI may best be used in a preclinical setting? Perhaps regarding disease progression in rodent models, or perhaps drug/vaccine efficacy studies.
Kindly follow this RG link
https://www.researchgate.net/publication/340840661_Findings_of_COVID-19_on_Magnetic_Resonance_Imaging
Signal Amplification by Reversible Exchange for COVID-19 Antiviral Drug
https://chemrxiv.org/articles/Chloroquine_and_Lopinavir_COVID-19_Drug_Candidates_Signal_Amplification_by_Reversible_Exchange/12055395/2
Have a look at it
https://chemrxiv.org/articles/Chloroquine_and_Lopinavir_COVID-19_Drug_Candidates_Signal_Amplification_by_Reversible_Exchange/12055395/2
