In gas-liquid counter-current flow, for example, flooding has to be avoided. It seems to be crucial to separate the phases as much as possible (see attached link). That means that the area of phase interphase must be small and this reduces probably the interaction of the phases.
The area of phase interface can be used to characterize flow patterns. For example, bubbly flow and annular flow can have the same void fraction but the area (or area density) of phase interface in bubbly flow is much larger.
I have no time to search the literature at the moment. I just want to point out this question, maybe someone knows publications or models that already use this concept.
Conference Paper COUNTER-CURRENT GAS/LIQUID FLOW THROUGH CHANNELS WITH CORRUG...