Especially when the immune system may be weakened.
Is there even research that shows, that it does exclusively migrate into the brain as seen in mice?
I had a lot to do with Toxoplasma gondii during the 1980s and early 1990s. I have not kept up with the literature in the last 20 years. But, as far as I am aware it does not reproduce sexually in humans, this only occurs in members of the cat family, felids. It does however reproduce asexually in humans. Dubey and others have published a large number of papers on host susceptibility to T. gondii and its development in different hosts.
you can refer to Dubey and others
you might find an answer to your question
There has not been any evidence on the produce of oocyst in human intestine entrocytes. It may be related to some receptors or signaling pathways needed in the specific host cells for the triggering sexual cycle. What takes your mind to this matter? If you faced some evidences in the lab or clinical cases?
Toxoplasma is not known to undergo sexual reproduction in the human intestine. As far as felids are concerned, one of the factors that influences sexual reproduction in the gut in domestic cats is whether a cat has previously been infected with the same strain of Toxoplasma. If it has, it might not shed any oocysts at all (because of immunity), whereas it can do so if reinfection is with a different strain of Toxoplasma (which the cat has not encountered previously). As regards the second part of your question, i.e. concerning extra-intestinal stages, Toxoplasma does not occur exclusively in (is not restricted to) the brain in felids, mice and humans. However, brain and muscle can contain a lot of cysts in chronic infections.
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