Put another way, is human insulin receptor sensitive to murine insulin? I know clinicians have used animal insulin (cow/bovine and pork) for over a century to treat diabetic patients, but I was wondering whether, say, human cancer cells implanted into a mouse are sensitive to mouse-produced insulin to take up glucose.
Any insight is appreciated!
Hi Eduardo,
in addition to the fact that mouse have 2 insulin genes, One of the differences is that humans lack a large part of the G protein-coupled receptors on the insulin-producing beta-cells that mice have and for which many drugs are developed. Of note, some of the receptors were only found in mice and others only in humans.
I know since I've got diabetes that I used long time ago some pork and bovine insulin, just by the simple fact that their genomes are closer to us than the murine one.
hope it helps
fred
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