I want to convert a carboxylic acid into Thio Acid using Lawesson's reagent. Based on the literature, this reaction requires a microwave reaction with Dichloromethane as an organic solvent, at 100 deg C for 10 minutes. The paper that I am referring to, doesn't provide complete information about this process. They just mention "A solution of carboxylic acid (0.50 mmol) and Lawesson’s Reagent (0.55 equivalence, 0.28 mmol) in CH2Cl2 (2.0 mL) in a sealed tube (for microwave reaction) was subjected to microwave irradiation (100 oC, 10 min). I wanted to enquire whether glass vials (with PTFE Teflon rubber caps) are suitable for this reaction in a microwave? Considering the low boiling point of DCM, is this reaction at 100 deg C possible in a sealed tube?
I would really appreciate your suggestions. Thank you so much
Check the experimental method for the model of the microwave. If it's given, you may be looking at a microwave-powered autoclave. If its not, might be a reagent microwave, likely with a thermocouple to measure temperature. As I do not have the capability to review the paper with credentials, I can't help here.
The major concern with sealed vessels is pressure, so proceed with caution! DCM is a finicky solvent, especially when hot, so proceed with caution. Best of luck with review!
@Curtis Guild: Thank you so much for your response. It seems sensible to monitor the temperature when using the microwave. I will try to locate and utilise this type of setup for this reaction. I appreciate your suggestions!
@V R Arun Prakash: Thank you for your answer
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