According to DF Swaab (2008: "Sexual orientation and its basis in brain structure and function", PNAS 105 (30): 10273-10274. DOI: 10.1073 / pnas.0805542105. PMC 2,492,513th PMID 18,653,758th"...) neurobiological research on sexual orientation man only gain momentum, and have already shown that people have a number of differences in the brain, not only in terms of gender, but also in relation to sexual orientation ... ". Svab was first announced that sexual orientation in men and biological "clock" located in the hypothalamus, in his suprachiazmatic nucleus.

In Journal of Eng. Proc Natl Acad Sci USA (2008) Ivanka Savic and Per Lindstrom, after conducting brain research of 25 heterosexual men and women and 20 lesbians and gay men, by the application of magnetic resonance volumetry of cerebral and cerebellar hemispheres, showed that the relationship between brain hemispheres, and the form amigdale connectivity, atypical in sexually different gay homosexual persons.

Laura Allen and Simon LeVay showed that two of the four anterior hypothalamic nuclei (INAH 2 and 3) are significantly higher in men than in women on the basis which it is hypothesized that dimorphism of these nuclei might accord to sexual orientation. Le Vayi hypothesized that (INAH 2 and 3) are higher in individuals sexually oriented toward women (heterosexual men and homosexual women) and lower in individuals sexually oriented toward men (heterosexual women and homosexual men).

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