I am doing some Bioinformatical analysis with all the aquaporins of human. But I am getting confused with this two. I don't find any reliable source regarding this.
This information was a bit hard to come by, but my findings lead me to believe that these are not subunits of the same protein, but rather distinct proteins.
According to the publication below, there are two separate genes for AQP12A and AQP12B, and AQP12A isoform 1 is 99% identical to AQP12B.
Calvanese, L., Pellegrini‐Calace, M., & Oliva, R. (2013). In silico study of human aquaporin AQP11 and AQP12 channels. Protein Science, 22(4), 455-466.
Looking deeper into it, I found out that the gene for AQP12B is a partial gene and seems to be a pseudogene, thus AQP12B likely modulates the stability of AQP12A.
Ishibashi, K., Hara, S., & Kondo, S. (2009). Aquaporin water channels in mammals. Clinical and experimental nephrology, 13(2), 107-117.
Hope this helps!
Amended on 10 December 2018
I have searched for Aquaporin in my protein database (please see file; HepG2 Fucoidan).
Only fetal hepatocyte Hc (obtained from USA) has expressed the Aquaporin-11at 3.9 μg/mg of cell protein. This may be due to species differences, or presence of human specific bacteria.
This cell has uniquely the Nuclease sbcCD subunit C (Treponeme pallidum) at 7.7 μg/mg of cell protein. Treponeme pallidum seems to be the up regulating bacteria for the Aquaporin-11.
On the other hand, Env polyprotein/Envelope glycoprotein gp160 (HIV type 2/HIV-2) is present at 3.1 μg/mg of cell protein in Hc cells. HIV-2 seems to be the down regulating virus.
It is interesting that both Treponeme pallidum and HIV-2 are human specific, and both are contagious through sexual act or sexual intercourse.
I am very grateful to Dr. Sorwer Alam Parvez (Department of Genetic Engineering and Biotechnology, Shahjalal University of Science and Technology, Sylhet, Bangladesh) for leading me to this important result.
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