After the death the circulatory system seizes. What happens to the chemical compound circulating in body? Are they deposited in the bone or do they settle down on bone surface?
Thanks Alejandro ..... but if the drug taken just before of death or person die because of Drug(narcotic) overdose in that case how we can evaluate?? that time, can bone help us??
yes, drugs are deposited into bone tissues and can be detected. I actually worked on detect 3 opoids in bone of rats after death by HPLC
thanks Melad.......R u found Codeine and Morphine??? I also working on same line but my approach is different.....
What about certain psychedelic drugs, like LSD, that actuate on very low dosages; is there any trace left in the bones after death?
Not all drugs can be deposited in bone, mainly heavy metals like lead can be, and can be detected from bone after death.
not all but heavy metal like As, Pb, Hg etc. can be found in bones after death and by knowing amount of heavy metals time since death can be known.
Because it depend upon the dose of drug that whether it is lethal or not, can be found in bones as well as other tissues and fluid of the body after death. There are many such technique, if you read instrumentation related to forensic science, by which one can detect the metal type and where it get deposited. So go through it.
I thnk the question needs to be reframed .Whether u want to know which drugs get deposited in bones or whether drugs get deposited after death? The meaning of deposition should be understood first. Presence of drugs or any other foriegn substance for that matter can be either due to circulatory process or as u said deposition -i.e.associated with calcification of the bone which is an antemortem process where it gets deeply ingrained into the bone.So the drugs cannot get deposited after death . If the drug at the moment of death(circulatory failure) were passing through vascular regions of the bone(bone marrow) ,they definitely wld stay back, but in the very superficial plane of the bone.So in acute cases u may find the drug or other foriegn substances only in the vascular bone marrow and not in the ossified areas as seen in chronic cases.
After death the way that chemical compounds can exist and act is only through diffusion. They will appear everywhere near the circulatory system and other organs, including the bone.
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