Regarding interpretation of sequence variants using ACMG rules.

Are ACMG rules PS3 and PP3 exclusionary?

In other words, if both PS3 and PP3 rules are fulfilled, can PP3 can be applied?

PS3 - Well-established in vitro or in vivo functional studies supportive of a damaging effect on the gene or gene product.

PP3 - Multiple lines of computational evidence support a deleterious effect on the gene or gene product -conservation, evolutionary, splicing impact, etc.

P.S - For me, they are not exclusionary.